? Fungal Infections on Nails and Skin: A Proven Nanotechnology Solution
What is it?
Onychomycosis (nail fungus) and dermatomycosis (skin fungus) are infections caused mainly by Trichophyton, Candida, and Aspergillus species. These thrive in warm, moist environments, leading to nail thickening, discoloration, flaking, itching, and skin discomfort (ScienceDirect).
Challenges with current treatments:
Oral antifungals (terbinafine, itraconazole) are effective but carry risks of liver toxicity. Topical treatments (ciclopirox, amorolfine) often fail due to poor penetration through the thick nail plate (PMC). Long treatment duration, high costs, and side effects cause many patients to abandon therapy
Cutting-edge solution: antifungal nanoparticles
- Silver nanoparticles (AgNPs) destroy fungal cell membranes, inhibit essential genes, and enhance traditional drug effects (Frontiers).
- Polymers and liposomes are engineered to penetrate nails and skin deeply, delivering higher drug concentrations locally with minimal systemic exposure.
- Metal oxides (e.g., silver oxide) show strong efficacy against C. albicans, A. fumigatus, and T. rubrum in vitro and in animal models (SpringerLink).
Research highlights:
- Nanoparticles combining nitric oxide + efinaconazole achieved the same antifungal effects with lower drug doses, reducing side effects and costs (GWU).
- Liposomal formulations reduced Candida albicans fungal load by over 60% compared to traditional treatments in infected skin models (Brown University).
Why does this matter for NanodefendePro?
NanodefendePro uses advanced nanoparticle technology to:
? Penetrate deep into nails and skin
? Deliver concentrated antifungal action at the infection site
? Reduce systemic side effects and irritation
Bottom line:
Science confirms that nanotechnology is the future of fungal treatment, offering safer, faster, and more effective results. NanodefendePro aligns with this innovation, providing a modern and scientifically supported solution to stubborn fungal infections.
